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D The stratification variables included time from analysis to first dose (< three years and ≥ 3 years), time from final prior systemic anti-lymphoma remedy to first dose (< 6 months and ≥ 6 months), prior SCT (yes or no), and MIPI at baseline (low, intermediate, and high danger).
In a retrospective research of sufferers with MDS (N = 1248, predominantly non-del5q) at the Moffitt Most cancers Center, together with 210 patients treated with lenalidomide, second main malignancies (SPM) were not related to lenalidomide treatment 35 Of the 41 SPM observed, 5 (2.four%) had been in patients handled with lenalidomide and 36 (3.5%) had been in patients treated with out lenalidomide.
side effects of lenalidomide and efficacy of lenalidomide was assessed in a part 3, multicenter, randomised, open-label, three-arm study (MM-020) of sufferers who have been at least sixty five years of age or older or, if youthful than sixty five years of age, weren't candidates for stem cell transplantation as a result of they declined to undergo stem cell transplantation or stem cell transplantation isn't available to the patient on account of cost or other examine (MM-020) in contrast lenalidomide and dexamethasone (Rd) given for two completely different durations of time (i.e., till progressive disease Arm Rd or for up to eighteen 28-day cycles 72 weeks, Arm Rd18) to melphalan, prednisone and thalidomide (MPT) for a maximum of twelve 42-day cycles (72 weeks).
Forty sufferers with recurrent and refractory T‐cell lymphomas aside from mycosis fungoides and sufferers with untreated T‐cell lymphoma who weren't candidates for combination chemotherapy have been prescribed oral lenalidomide at a dose of 25 mg daily on days 1 to 21 of every 28‐day cycle, with standardized dose reductions for toxicity.